{"id":227383,"date":"2025-12-18T10:11:32","date_gmt":"2025-12-18T16:11:32","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/abstract-a-widely-held-hypothesis-posits-that-er-stress-drives-cell-death-in-thyroid-disease"},"modified":"2025-12-18T10:11:32","modified_gmt":"2025-12-18T16:11:32","slug":"abstract-a-widely-held-hypothesis-posits-that-er-stress-drives-cell-death-in-thyroid-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/abstract-a-widely-held-hypothesis-posits-that-er-stress-drives-cell-death-in-thyroid-disease","title":{"rendered":"Abstract: A widely held hypothesis posits that ER stress drives cell death in thyroid disease"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract36.jpg\"><\/a><\/p>\n<p>Here, Peter Arvan &amp; team generate a mouse model lacking thyroglobulin, finding stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress:<\/p>\n<p>The figure shows limited ER diameter in thyroid tissue from Tg-KO untreated mice.<\/p>\n<hr>\n<p>Address correspondence to: Peter Arvan, Division of Metabolism, <i>Endocrinology<\/i> &amp; Diabetes, University of Michigan, Brehm Tower rm 5,112, 1000 Wall Street, Ann Arbor, Michigan 48,105, USA. Phone: 734.936.5505; Email: <a href=\"mailto:parvan@umich.edu.\">parvan@umich.edu.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here, Peter Arvan &amp; team generate a mouse model lacking thyroglobulin, finding stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress: The figure shows limited ER diameter in thyroid tissue from Tg-KO untreated mice. Address correspondence to: Peter Arvan, Division of Metabolism, Endocrinology &amp; Diabetes, University of Michigan, Brehm Tower rm [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1512],"tags":[],"class_list":["post-227383","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-mobile-phones"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227383","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227383"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227383\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227383"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227383"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227383"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}