{"id":227301,"date":"2025-12-17T01:41:31","date_gmt":"2025-12-17T07:41:31","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/psilocybin-shows-greater-potential-than-cannabinoids-for-obsessive-compulsive-disorder-treatment"},"modified":"2025-12-17T01:41:31","modified_gmt":"2025-12-17T07:41:31","slug":"psilocybin-shows-greater-potential-than-cannabinoids-for-obsessive-compulsive-disorder-treatment","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/psilocybin-shows-greater-potential-than-cannabinoids-for-obsessive-compulsive-disorder-treatment","title":{"rendered":"Psilocybin shows greater potential than cannabinoids for obsessive-compulsive disorder treatment"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/psilocybin-shows-greater-potential-than-cannabinoids-for-obsessive-compulsive-disorder-treatment.jpg\"><\/a><\/p>\n<p>In a review of previous studies, McMaster University researchers observe a stronger signal for psilocybin as a treatment for obsessive-compulsive disorder than cannabinoids.<\/p>\n<p>Obsessive-compulsive disorder involves persistent, intrusive thoughts and repetitive mental or physical behaviors, and requires long-term treatment to alleviate symptoms. The ethology of the disorder appears complex, involving multiple biological pathways. Imbalances in central <a href=\"https:\/\/medicalxpress.com\/news\/2023-06-chemical-imbalance-forebrain-underpins-compulsive.html?utm_source=embeddings&utm_medium=related&utm_campaign=internal\" rel=\"related\">serotonin<\/a>, dopamine, and glutamate activities are widely thought to play a causative role, placing neurochemistry at the center of many treatment strategies.<\/p>\n<p>First-line treatment includes selective serotonin reuptake inhibitors and cognitive behavioral therapy using exposure and response prevention. Roughly 40\u201360% of patients remain unresponsive to psychotherapy or pharmacotherapy, alone or combined, placing many people in the category of treatment-resistant OCD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a review of previous studies, McMaster University researchers observe a stronger signal for psilocybin as a treatment for obsessive-compulsive disorder than cannabinoids. Obsessive-compulsive disorder involves persistent, intrusive thoughts and repetitive mental or physical behaviors, and requires long-term treatment to alleviate symptoms. The ethology of the disorder appears complex, involving multiple biological pathways. Imbalances in [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,19,47],"tags":[],"class_list":["post-227301","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-chemistry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227301","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227301"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227301\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227301"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227301"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227301"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}