{"id":227230,"date":"2025-12-16T17:19:42","date_gmt":"2025-12-16T23:19:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/while-studying-the-effects-of-glutamine-deprivation-boa-kim-team-noticed-dramatic-clustering-of-glutaminase-throughout-endothelial-cells"},"modified":"2025-12-16T17:19:42","modified_gmt":"2025-12-16T23:19:42","slug":"while-studying-the-effects-of-glutamine-deprivation-boa-kim-team-noticed-dramatic-clustering-of-glutaminase-throughout-endothelial-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/while-studying-the-effects-of-glutamine-deprivation-boa-kim-team-noticed-dramatic-clustering-of-glutaminase-throughout-endothelial-cells","title":{"rendered":"While studying the effects of glutamine deprivation, Boa Kim &amp; team noticed dramatic clustering of glutaminase throughout endothelial cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/while-studying-the-effects-of-glutamine-deprivation-boa-kim-team-noticed-dramatic-clustering-of-glutaminase-throughout-endothelial-cells2.jpg\"><\/a><\/p>\n<p>The team now report on a mechanism underlying kidney tumor cell growth involving the cancer-driving protein HIF2\u03b1 that blocks clustering\/activation of glutaminase\u2014revealing a new therapeutic target in renal clear cell carcinoma:<\/p>\n<p>The figure shows glutamine deprivation induces GLS1 clustering within mitochondria in HUVEC (top) and HELA (bottom) with mitochondrial protein (green) and GLS (red).<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Department of Medicine, Cardiovascular Institute, and Institute of Diabetes Obesity and Metabolism, and.<\/p>\n<p><sup>2<\/sup>The Abramson Family <i>Cancer Res<\/i>earch Institute, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<\/p>\n<p><sup>3<\/sup>McAllister Heart Institute, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The team now report on a mechanism underlying kidney tumor cell growth involving the cancer-driving protein HIF2\u03b1 that blocks clustering\/activation of glutaminase\u2014revealing a new therapeutic target in renal clear cell carcinoma: The figure shows glutamine deprivation induces GLS1 clustering within mitochondria in HUVEC (top) and HELA (bottom) with mitochondrial protein (green) and GLS (red). 1Department [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-227230","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227230"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227230\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}