{"id":227147,"date":"2025-12-15T14:21:08","date_gmt":"2025-12-15T20:21:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/abstract-from-synaptogenic-to-synaptotoxic"},"modified":"2025-12-15T14:21:08","modified_gmt":"2025-12-15T20:21:08","slug":"abstract-from-synaptogenic-to-synaptotoxic","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/abstract-from-synaptogenic-to-synaptotoxic","title":{"rendered":"Abstract: From synaptogenic to synaptotoxic"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract32.jpg\"><\/a><\/p>\n<p>This issue\u2019s cover features work by Alberto Siddu &amp; team on the promotion of synapse formation in human neurons by free amyloid-beta peptides, in contrast to aggregated forms that are synaptotoxic:<\/p>\n<p>The image shows a human induced neuron exposed to a nontoxic concentration of amyloid-beta42 peptide, revealing enhanced synaptogenesis, visible as synaptic puncta along the dendritic arbor.<\/p>\n<hr>\n<p>Address correspondence to: Alberto Siddu, Lorry Lokey Stem Cell Building, 265 Campus Dr., Room G1015, Stanford, California 94,305, USA. Phone: 650.721.1418; Email: <a href=\"mailto:asiddu@stanford.edu.\">asiddu@stanford.edu.<\/a> Or to: Thomas C. S\u00fcdhof, Lorry Lokey Stem Cell Building, 265 Campus Dr., Room G1021, Stanford, California 94,305, USA. Phone: 650.721.1418; Email: <a href=\"mailto:tcs1@stanford.edu.\">tcs1@stanford.edu.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This issue\u2019s cover features work by Alberto Siddu &amp; team on the promotion of synapse formation in human neurons by free amyloid-beta peptides, in contrast to aggregated forms that are synaptotoxic: The image shows a human induced neuron exposed to a nontoxic concentration of amyloid-beta42 peptide, revealing enhanced synaptogenesis, visible as synaptic puncta along the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1512,47],"tags":[],"class_list":["post-227147","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-mobile-phones","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227147"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227147\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}