{"id":227141,"date":"2025-12-15T09:17:33","date_gmt":"2025-12-15T15:17:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/characterizing-fibroblast-heterogeneity-in-diabetic-wounds-through-single-cell-rna-sequencing"},"modified":"2025-12-15T09:17:33","modified_gmt":"2025-12-15T15:17:33","slug":"characterizing-fibroblast-heterogeneity-in-diabetic-wounds-through-single-cell-rna-sequencing","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/characterizing-fibroblast-heterogeneity-in-diabetic-wounds-through-single-cell-rna-sequencing","title":{"rendered":"Characterizing Fibroblast Heterogeneity in Diabetic Wounds Through Single-Cell RNA-Sequencing"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/characterizing-fibroblast-heterogeneity-in-diabetic-wounds-through-single-cell-rna-sequencing2.jpg\"><\/a><\/p>\n<p>DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress.<\/p>\n<hr>\n<p>Shawky et al. show that DDX3X selectively promotes or represses mRNA translation in a stress-dependent manner. This bidirectional regulation involves position-specific binding to the mRNA 5\u2032 UTR and early coding region, reflecting distinct mechanisms, including initiation control during 48S scanning and translational repression associated with ac4C post-transcriptional modification.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress. Shawky et al. show that DDX3X selectively promotes or represses mRNA translation in a stress-dependent manner. This bidirectional regulation involves position-specific binding to the mRNA 5\u2032 UTR and early coding region, reflecting distinct mechanisms, including initiation control during 48S scanning [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-227141","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=227141"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/227141\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=227141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=227141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=227141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}