{"id":226949,"date":"2025-12-11T21:07:52","date_gmt":"2025-12-12T03:07:52","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/oncogenic-ras-activation-in-permissive-somatic-cells-triggers-rapid-onset-phenotypic-plasticity-and-elicits-a-tumor-promoting-neutrophil-response"},"modified":"2025-12-11T21:07:52","modified_gmt":"2025-12-12T03:07:52","slug":"oncogenic-ras-activation-in-permissive-somatic-cells-triggers-rapid-onset-phenotypic-plasticity-and-elicits-a-tumor-promoting-neutrophil-response","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/oncogenic-ras-activation-in-permissive-somatic-cells-triggers-rapid-onset-phenotypic-plasticity-and-elicits-a-tumor-promoting-neutrophil-response","title":{"rendered":"Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/oncogenic-ras-activation-in-permissive-somatic-cells-triggers-rapid-onset-phenotypic-plasticity-and-elicits-a-tumor-promoting-neutrophil-response2.jpg\"><\/a><\/p>\n<p>Ras mutations drive tumorigenesis yet persist in normal tissues. Elliot et al. explore this paradox, finding that HRASG12V induces bifurcating cell fates in the zebrafish larval epidermis, with lamc2+krt18+ cancer stem cell-like cells emerging from permissive cells at the preneoplastic stage and expressing neutrophil-modulating cytokines that instigate reciprocal tumor-supportive crosstalk.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ras mutations drive tumorigenesis yet persist in normal tissues. Elliot et al. explore this paradox, finding that HRASG12V induces bifurcating cell fates in the zebrafish larval epidermis, with lamc2+krt18+ cancer stem cell-like cells emerging from permissive cells at the preneoplastic stage and expressing neutrophil-modulating cytokines that instigate reciprocal tumor-supportive crosstalk.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-226949","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226949"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226949\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226949"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}