{"id":226936,"date":"2025-12-11T13:17:31","date_gmt":"2025-12-11T19:17:31","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/tricking-tumors-into-marking-themselves-for-destruction-with-focused-ultrasound"},"modified":"2025-12-11T13:17:31","modified_gmt":"2025-12-11T19:17:31","slug":"tricking-tumors-into-marking-themselves-for-destruction-with-focused-ultrasound","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/tricking-tumors-into-marking-themselves-for-destruction-with-focused-ultrasound","title":{"rendered":"Tricking tumors into marking themselves for destruction with focused ultrasound"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/tricking-tumors-into-marking-themselves-for-destruction-with-focused-ultrasound2.jpg\"><\/a><\/p>\n<p>USC biomedical engineers have found a way to make a solid tumor paint a target on its own back in order to train the body\u2019s immune system to find and destroy it.<\/p>\n<p>The research team from USC Viterbi\u2019s Wang Lab used focused ultrasound waves to \u201cprime\u201d tumor cells so they can be more easily recognized and attacked by chimeric antigen receptor (CAR) T-cells, the engineered immune cells that have revolutionized treatment for blood cancers but have until now struggled against solid tumors. The research has been <a href=\"https:\/\/www.nature.com\/articles\/s41563-025-02391-8\" target=\"_blank\">published<\/a> in Nature Materials.<\/p>\n<p>CAR T-cell therapy works remarkably well in the bloodstream, where rogue cancer cells are exposed and easily targeted. However, solid tumors are another story. They hide deep in tissue, shielded by a microenvironment fortress of healthy cells. Every tumor is different, making it hard to find a single \u201cflag\u201d that marks cancer cells without causing damage to healthy ones.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>USC biomedical engineers have found a way to make a solid tumor paint a target on its own back in order to train the body\u2019s immune system to find and destroy it. The research team from USC Viterbi\u2019s Wang Lab used focused ultrasound waves to \u201cprime\u201d tumor cells so they can be more easily recognized [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-226936","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226936","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226936"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226936\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226936"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226936"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}