{"id":226922,"date":"2025-12-11T10:11:36","date_gmt":"2025-12-11T16:11:36","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/abstract-the-mechanistic-basis-of-chronic-liver-disease-is-still-only-partially-understood"},"modified":"2025-12-11T10:11:36","modified_gmt":"2025-12-11T16:11:36","slug":"abstract-the-mechanistic-basis-of-chronic-liver-disease-is-still-only-partially-understood","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/abstract-the-mechanistic-basis-of-chronic-liver-disease-is-still-only-partially-understood","title":{"rendered":"Abstract: The mechanistic basis of chronic liver disease is still only partially understood"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/abstract26.jpg\"><\/a><\/p>\n<p>Harmeet Malhi &amp; team discover ER-stress mediated <i>S100A11<\/i> upregulation drives progression of fatty liver disease, revealing a new target for future treatments:<\/p>\n<p>The figure shows reduction within the high-fat,-fructose, and-cholesterol,-lipotoxicity-influenced enhancer (FFC-LIE) mouse groups compared with FFC-scramble controls.<\/p>\n<hr>\n<p>Address correspondence to: Harmeet Malhi, Division of <i>Gastroenterology<\/i> and <i>Hepatology<\/i>, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55,905, USA. Phone: 507.284.0686; Email: <a href=\"mailto:Malhi.harmeet@mayo.edu.\">Malhi.harmeet@mayo.edu.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Harmeet Malhi &amp; team discover ER-stress mediated S100A11 upregulation drives progression of fatty liver disease, revealing a new target for future treatments: The figure shows reduction within the high-fat,-fructose, and-cholesterol,-lipotoxicity-influenced enhancer (FFC-LIE) mouse groups compared with FFC-scramble controls. Address correspondence to: Harmeet Malhi, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1512],"tags":[],"class_list":["post-226922","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-mobile-phones"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226922","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226922"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226922\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226922"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226922"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226922"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}