{"id":226869,"date":"2025-12-10T21:11:00","date_gmt":"2025-12-11T03:11:00","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/preta-mediated-metabolism-of-5-fluorouracil-by-intratumoral-citrobacter-freundii-drives-chemoresistance-in-pancreatic-cancer"},"modified":"2025-12-10T21:11:00","modified_gmt":"2025-12-11T03:11:00","slug":"preta-mediated-metabolism-of-5-fluorouracil-by-intratumoral-citrobacter-freundii-drives-chemoresistance-in-pancreatic-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/preta-mediated-metabolism-of-5-fluorouracil-by-intratumoral-citrobacter-freundii-drives-chemoresistance-in-pancreatic-cancer","title":{"rendered":"PreTA-mediated metabolism of 5-fluorouracil by intratumoral Citrobacter freundii drives chemoresistance in pancreatic cancer"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/preta-mediated-metabolism-of-5-fluorouracil-by-intratumoral-citrobacter-freundii-drives-chemoresistance-in-pancreatic-cancer2.jpg\"><\/a><\/p>\n<p>Xu et al. report that intratumoral <i>Citrobacter<\/i> enrichment correlates with poor overall survival in pancreatic cancer patients. An intratumoral <i><i>Citrobacter<\/i> <i>freundii<\/i><\/i> strain metabolizes 5-fluorouracil (5-FU) into inactive products via PreTA. Gimeracil, an inhibitor of human dihydropyrimidine dehydrogenase, preserves 5-FU efficacy by blocking PreTA activity.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xu et al. report that intratumoral Citrobacter enrichment correlates with poor overall survival in pancreatic cancer patients. An intratumoral Citrobacter freundii strain metabolizes 5-fluorouracil (5-FU) into inactive products via PreTA. Gimeracil, an inhibitor of human dihydropyrimidine dehydrogenase, preserves 5-FU efficacy by blocking PreTA activity.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-226869","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226869"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226869\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}