{"id":226860,"date":"2025-12-10T17:19:24","date_gmt":"2025-12-10T23:19:24","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/multiple-modes-of-transcriptional-regulation-by-the-nuclear-hormone-receptor-rar%ce%b3-in-human-squamous-cell-carcinoma"},"modified":"2025-12-10T17:19:24","modified_gmt":"2025-12-10T23:19:24","slug":"multiple-modes-of-transcriptional-regulation-by-the-nuclear-hormone-receptor-rar%ce%b3-in-human-squamous-cell-carcinoma","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/multiple-modes-of-transcriptional-regulation-by-the-nuclear-hormone-receptor-rar%ce%b3-in-human-squamous-cell-carcinoma","title":{"rendered":"Multiple modes of transcriptional regulation by the nuclear hormone receptor RAR\u03b3 in human squamous cell carcinoma"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/multiple-modes-of-transcriptional-regulation-by-the-nuclear-hormone-receptor-rarceb3-in-human-squamous-cell-carcinoma2.jpg\"><\/a><\/p>\n<p>Vitamin A metabolism and signaling through nuclear retinoic acid receptors (RARs \u03b1,\u03b2,\u03b3) regulate embryogenesis, immune functions, and cell differentiation in most cell types. RAR\u03b3 is highly expressed in stratified squamous epithelial cells of the oral cavity and skin. While data indicate that RAR\u03b3 agonism is anti-tumorigenic in oral cavity squamous cell carcinoma (OCSCC), the specific, primary gene targets of RAR\u03b3 remain poorly characterized. Here, we define RAR\u03b3 signaling pathways through integrating genome-wide RAR\u03b3 binding by Cleavage under Targets and Release Using Nuclease (CUT&amp;RUN), chromatin histone marks, and global transcriptomics \u00b1 agonists in human OCSCC cells and in human OCSCC cells with deletion of RARG (RARGKO).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Vitamin A metabolism and signaling through nuclear retinoic acid receptors (RARs \u03b1,\u03b2,\u03b3) regulate embryogenesis, immune functions, and cell differentiation in most cell types. RAR\u03b3 is highly expressed in stratified squamous epithelial cells of the oral cavity and skin. While data indicate that RAR\u03b3 agonism is anti-tumorigenic in oral cavity squamous cell carcinoma (OCSCC), the specific, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-226860","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226860","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226860"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226860\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226860"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226860"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226860"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}