{"id":226795,"date":"2025-12-09T21:06:11","date_gmt":"2025-12-10T03:06:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/optimal-cxcr5-expression-during-tfh-maturation-involves-the-bhlhe40-pou2af1-axis"},"modified":"2025-12-09T21:06:11","modified_gmt":"2025-12-10T03:06:11","slug":"optimal-cxcr5-expression-during-tfh-maturation-involves-the-bhlhe40-pou2af1-axis","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/optimal-cxcr5-expression-during-tfh-maturation-involves-the-bhlhe40-pou2af1-axis","title":{"rendered":"Optimal CXCR5 expression during Tfh maturation involves the Bhlhe40-Pou2af1 axis"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/optimal-cxcr5-expression-during-tfh-maturation-involves-the-bhlhe40-pou2af1-axis2.jpg\"><\/a><\/p>\n<p>The Bcl6-Blimp-1 axis plays a critical role in follicular T helper (Tfh) cell fate determination; however, the regulation of CXCR5 expression during Tfh maturation is still elusive. Zhu et al. report that the <i>Bhlhe40<\/i>-<i>Pou2af1<\/i> pair regulates optimal expression of CXCR5 and Tfh cell migration into germinal centers without affecting Bcl6 induction.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Bcl6-Blimp-1 axis plays a critical role in follicular T helper (Tfh) cell fate determination; however, the regulation of CXCR5 expression during Tfh maturation is still elusive. Zhu et al. report that the Bhlhe40-Pou2af1 pair regulates optimal expression of CXCR5 and Tfh cell migration into germinal centers without affecting Bcl6 induction.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-226795","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226795","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226795"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226795\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226795"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226795"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226795"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}