{"id":226778,"date":"2025-12-09T09:12:14","date_gmt":"2025-12-09T15:12:14","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/a-new-approach-for-detecting-retinal-disease-variants-at-the-transcript-level-from-blood-and-skin-cells"},"modified":"2025-12-09T09:12:14","modified_gmt":"2025-12-09T15:12:14","slug":"a-new-approach-for-detecting-retinal-disease-variants-at-the-transcript-level-from-blood-and-skin-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/a-new-approach-for-detecting-retinal-disease-variants-at-the-transcript-level-from-blood-and-skin-cells","title":{"rendered":"A new approach for detecting retinal disease variants at the transcript level from blood and skin cells"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-new-approach-for-detecting-retinal-disease-variants-at-the-transcript-level-from-blood-and-skin-cells.jpg\"><\/a><\/p>\n<p>Using a CRISPRa-based approach, Elvir Becirovic &amp; team activated retinal disease-related genes in isolated human cells, establishing a minimally invasive diagnostic method for inherited retinal diseases:<\/p>\n<p>The fundus autofluorescence image is from a patient with confirmed <i>ABCA4-<\/i>associated retinal disease (STGD1).<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Laboratory for Retinal <i>Gene Ther <\/i>apy, Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.<\/p>\n<p><sup>2<\/sup>Department of Ophthalmology, LMU University Hospital, LMU Munich, Munich, Germany.<\/p>\n<p><sup>3<\/sup>Department of Pharmacy \u2013 Center for Drug Research, LMU Munich, Munich, Germany.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using a CRISPRa-based approach, Elvir Becirovic &amp; team activated retinal disease-related genes in isolated human cells, establishing a minimally invasive diagnostic method for inherited retinal diseases: The fundus autofluorescence image is from a patient with confirmed ABCA4-associated retinal disease (STGD1). 1Laboratory for Retinal Gene Ther apy, Department of Ophthalmology, University Hospital Zurich, University of Zurich, [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-226778","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226778"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226778\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}