{"id":226765,"date":"2025-12-09T01:35:38","date_gmt":"2025-12-09T07:35:38","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/mice-generated-with-induced-pluripotent-stem-cells-derived-from-mucosal-associated-invariant-t-cells"},"modified":"2025-12-09T01:35:38","modified_gmt":"2025-12-09T07:35:38","slug":"mice-generated-with-induced-pluripotent-stem-cells-derived-from-mucosal-associated-invariant-t-cells","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/mice-generated-with-induced-pluripotent-stem-cells-derived-from-mucosal-associated-invariant-t-cells","title":{"rendered":"Mice Generated with Induced Pluripotent Stem Cells Derived from Mucosal-Associated Invariant T Cells"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mice-generated-with-induced-pluripotent-stem-cells-derived-from-mucosal-associated-invariant-t-cells.jpg\"><\/a><\/p>\n<p>The function of mucosal-associated invariant T (MAIT) cells, a burgeoning member of innate-like T cells abundant in humans and implicated in many diseases, remains obscure. To explore this, mice with a rearranged T cell receptor (TCR) \u03b1 or \u03b2 locus, specific for MAIT cells, were generated via induced pluripotent stem cells derived from MAIT cells and were designated V\u03b119 and V\u03b28 mice, respectively. Both groups of mice expressed large numbers of MAIT cells. The MAIT cells from these mice were activated by cytokines and an agonist to produce IFN-\u03b3 and IL-17. While V\u03b28 mice showed resistance in a cancer metastasis model, V\u03b119 mice did not. Adoptive transfer of MAIT cells from the latter into the control mice, however, recapitulated the resistance.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The function of mucosal-associated invariant T (MAIT) cells, a burgeoning member of innate-like T cells abundant in humans and implicated in many diseases, remains obscure. To explore this, mice with a rearranged T cell receptor (TCR) \u03b1 or \u03b2 locus, specific for MAIT cells, were generated via induced pluripotent stem cells derived from MAIT cells [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-226765","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226765"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226765\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}