{"id":226583,"date":"2025-12-06T00:02:43","date_gmt":"2025-12-06T06:02:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/next-gen-cancer-drug-shows-surprising-anti-aging-power"},"modified":"2025-12-06T00:02:43","modified_gmt":"2025-12-06T06:02:43","slug":"next-gen-cancer-drug-shows-surprising-anti-aging-power","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/next-gen-cancer-drug-shows-surprising-anti-aging-power","title":{"rendered":"Next gen cancer drug shows surprising anti aging power"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/next-gen-cancer-drug-shows-surprising-anti-aging-power.webp\"><\/a><\/p>\n<p>The study unexpectedly identified a significant role for a group of enzymes known as agmatinases, which convert the metabolite agmatine into polyamines. These enzymes appear to participate in a previously unrecognized \u201cmetabolic feedback loop\u201d that helps maintain balanced TOR activity. When agmatinase activity was disrupted, yeast cells grew more quickly but showed signs of premature aging, revealing a trade-off between rapid growth and long-term cell survival.<\/p>\n<p>The team also found that adding agmatine or putrescine (a related compound) supported longevity in yeast and improved growth under specific conditions.<\/p>\n<p>\u201cBy showing that agmatinases are essential for healthy aging, we\u2019ve uncovered a new layer of metabolic control over TOR \u2014 one that may be conserved in humans,\u201d said Dr. Rallis. \u201cBecause agmatine is produced by diet and gut microbes, this work may help explain how nutrition and the microbiome influence aging.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The study unexpectedly identified a significant role for a group of enzymes known as agmatinases, which convert the metabolite agmatine into polyamines. These enzymes appear to participate in a previously unrecognized \u201cmetabolic feedback loop\u201d that helps maintain balanced TOR activity. When agmatinase activity was disrupted, yeast cells grew more quickly but showed signs of premature [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-226583","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226583"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226583\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}