{"id":226552,"date":"2025-12-05T00:40:23","date_gmt":"2025-12-05T06:40:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/footnotes-claudin-2-deficiency-reveals-a-corticomedullary-calcium-gradient-driving-kidney-stone-formation"},"modified":"2025-12-05T00:40:23","modified_gmt":"2025-12-05T06:40:23","slug":"footnotes-claudin-2-deficiency-reveals-a-corticomedullary-calcium-gradient-driving-kidney-stone-formation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/footnotes-claudin-2-deficiency-reveals-a-corticomedullary-calcium-gradient-driving-kidney-stone-formation","title":{"rendered":"Footnotes: Claudin-2 deficiency reveals a corticomedullary calcium gradient driving kidney stone formation:"},"content":{"rendered":"<p><a class=\"blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/footnotes.jpg\"><\/a><\/p>\n<p>Benjamin D. Humphreys provides an Editor\u2019s Note on Christine V. Behm et al. <a href=\"https:\/\/doi.org\/10.1172\/JCI197807\">https:\/\/doi.org\/10.1172\/JCI197807<\/a><\/p>\n<p>The figure from Behm et al. shows nephrocalcinosis in older kidney-specific Cldn2-KO mice.<\/p>\n<hr>\n<p>Deposits of hydroxyapatite called Randall\u2019s plaques are found in the renal papilla of calcium oxalate kidney stone formers and likely serve as the nidus for stone formation, but their pathogenesis is unknown. Claudin-2 is a paracellular ion channel that mediates calcium reabsorption in the renal proximal tubule. To investigate the role of renal claudin-2, we generated kidney tubule\u2013specific claudin-2 conditional KO mice (KS-Cldn2 KO). KS-Cldn2 KO mice exhibited transient hypercalciuria in early life. Normalization of urine calcium was accompanied by a compensatory increase in expression and function of renal tubule calcium transporters, including in the thick ascending limb. Despite normocalciuria, KS-Cldn2 KO mice developed papillary hydroxyapatite deposits, beginning at 6 months of age, that resembled Randall\u2019s plaques and tubule plugs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Benjamin D. Humphreys provides an Editor\u2019s Note on Christine V. Behm et al. https:\/\/doi.org\/10.1172\/JCI197807 The figure from Behm et al. shows nephrocalcinosis in older kidney-specific Cldn2-KO mice. Deposits of hydroxyapatite called Randall\u2019s plaques are found in the renal papilla of calcium oxalate kidney stone formers and likely serve as the nidus for stone formation, but [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"class_list":["post-226552","post","type-post","status-publish","format-standard","hentry","category-futurism"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226552","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226552"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226552\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}