{"id":226401,"date":"2025-12-03T08:03:25","date_gmt":"2025-12-03T14:03:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/a-bcl-xl-bcl-2-protac-effectively-clears-senescent-cells-in-the-liver-and-reduces-mash-driven-hepatocellular-carcinoma-in-mice"},"modified":"2025-12-03T08:03:25","modified_gmt":"2025-12-03T14:03:25","slug":"a-bcl-xl-bcl-2-protac-effectively-clears-senescent-cells-in-the-liver-and-reduces-mash-driven-hepatocellular-carcinoma-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/a-bcl-xl-bcl-2-protac-effectively-clears-senescent-cells-in-the-liver-and-reduces-mash-driven-hepatocellular-carcinoma-in-mice","title":{"rendered":"A BCL-xL\/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/a-bcl-xl-bcl-2-protac-effectively-clears-senescent-cells-in-the-liver-and-reduces-mash-driven-hepatocellular-carcinoma-in-mice.jpg\"><\/a><\/p>\n<p>Yang, Jn-Simon, He <i>et al.<\/i> report that the dual BCL-xL\/BCL-2 PROTAC 753b is a potent and liver-tropic senolytic, which (unlike other inhibitors of BCL-xL) does not cause severe thrombocytopenia. They evaluate its efficacy in natural aging and in reducing progression from steatotic liver disease to hepatocellular carcinoma, using mouse models.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yang, Jn-Simon, He et al. report that the dual BCL-xL\/BCL-2 PROTAC 753b is a potent and liver-tropic senolytic, which (unlike other inhibitors of BCL-xL) does not cause severe thrombocytopenia. They evaluate its efficacy in natural aging and in reducing progression from steatotic liver disease to hepatocellular carcinoma, using mouse models.<\/p>\n","protected":false},"author":367,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-226401","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/367"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226401"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226401\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226401"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226401"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}