{"id":226337,"date":"2025-12-02T21:10:42","date_gmt":"2025-12-03T03:10:42","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/p-rex1-limits-the-agonist-induced-internalization-of-gpcrs-independently-of-its-rac-gef-activity"},"modified":"2025-12-02T21:10:42","modified_gmt":"2025-12-03T03:10:42","slug":"p-rex1-limits-the-agonist-induced-internalization-of-gpcrs-independently-of-its-rac-gef-activity","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/p-rex1-limits-the-agonist-induced-internalization-of-gpcrs-independently-of-its-rac-gef-activity","title":{"rendered":"P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/p-rex1-limits-the-agonist-induced-internalization-of-gpcrs-independently-of-its-rac-gef-activity2.jpg\"><\/a><\/p>\n<p>P-Rex1 activates Rac downstream of GPCRs to regulate processes ranging from innate immunity to neuronal plasticity, its deregulation contributing to cancer. Here, Baker et al. show that P-Rex1 also controls GPCR trafficking, limiting agonist-induced GPCR internalization through an adapter function. Thus, P-Rex1 promotes GPCR responses in a dual manner.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>P-Rex1 activates Rac downstream of GPCRs to regulate processes ranging from innate immunity to neuronal plasticity, its deregulation contributing to cancer. Here, Baker et al. show that P-Rex1 also controls GPCR trafficking, limiting agonist-induced GPCR internalization through an adapter function. Thus, P-Rex1 promotes GPCR responses in a dual manner.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-226337","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226337"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226337\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226337"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}