{"id":226290,"date":"2025-12-02T00:42:37","date_gmt":"2025-12-02T06:42:37","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/factor-h-related-protein-1-fhr1-a-promotor-of-para-inflammation-in-age-related-macular-degeneration"},"modified":"2025-12-02T00:42:37","modified_gmt":"2025-12-02T06:42:37","slug":"factor-h-related-protein-1-fhr1-a-promotor-of-para-inflammation-in-age-related-macular-degeneration","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/factor-h-related-protein-1-fhr1-a-promotor-of-para-inflammation-in-age-related-macular-degeneration","title":{"rendered":"Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/factor-h-related-protein-1-fhr1-a-promotor-of-para-inflammation-in-age-related-macular-degeneration3.jpg\"><\/a><\/p>\n<p>Age-related macular degeneration (AMD), a multifactorial type of retinal degeneration represents the most common cause for blindness in elderly. Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases the AMD risk, currently explained by their opposing relationship. Here we identify a FHR1-driven pathway fostering chronic cellular inflammation. FHR1 accumulates below the retinal pigment epithelium (RPE) in AMD donor tissue and similarly the murine homolog, <i>muFHR1<\/i> is abundant in three AMD-relevant mouse models. These mouse models express the <i>muFHR1<\/i> receptor EGF-like module-containing mucin-like hormone receptor 1 (Emr1) on the RPE and on invading mononuclear phagocytes (MP), where both cells form clusters via <i>muFHR1<\/i>\/Emr1.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Age-related macular degeneration (AMD), a multifactorial type of retinal degeneration represents the most common cause for blindness in elderly. Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases the AMD risk, currently explained by their opposing relationship. Here we identify a FHR1-driven pathway fostering chronic cellular inflammation. FHR1 accumulates below the retinal [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[269],"tags":[],"class_list":["post-226290","post","type-post","status-publish","format-standard","hentry","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226290","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226290"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226290\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226290"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226290"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226290"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}