{"id":226237,"date":"2025-12-01T12:04:57","date_gmt":"2025-12-01T18:04:57","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/12\/engineered-immune-cells-target-and-destroy-glioblastoma-in-animal-models"},"modified":"2025-12-01T12:04:57","modified_gmt":"2025-12-01T18:04:57","slug":"engineered-immune-cells-target-and-destroy-glioblastoma-in-animal-models","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/12\/engineered-immune-cells-target-and-destroy-glioblastoma-in-animal-models","title":{"rendered":"Engineered immune cells target and destroy glioblastoma in animal models"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/engineered-immune-cells-target-and-destroy-glioblastoma-in-animal-models2.jpg\"><\/a><\/p>\n<p>With a five-year survival rate of less than 5%, glioblastoma is one of the most aggressive types of brain cancer. Until now, all available treatments, including immunotherapy\u2014which involves strengthening the immune system to fight cancer\u2014have proved disappointing. CAR-T cells are genetically modified immune cells manufactured in the laboratory and designed to identify and destroy cancer cells.<\/p>\n<p>By targeting a protein present in the tumor environment, a team from the University of Geneva (UNIGE) and the Geneva University Hospital (HUG) has developed CAR-T cells capable of destroying glioblastoma cells. Their efficacy in an animal model of the disease paves the way for clinical trials in humans.<\/p>\n<p>The results are published in the Journal for ImmunoTherapy of Cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>With a five-year survival rate of less than 5%, glioblastoma is one of the most aggressive types of brain cancer. Until now, all available treatments, including immunotherapy\u2014which involves strengthening the immune system to fight cancer\u2014have proved disappointing. CAR-T cells are genetically modified immune cells manufactured in the laboratory and designed to identify and destroy cancer [\u2026]<\/p>\n","protected":false},"author":707,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,47],"tags":[],"class_list":["post-226237","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/707"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226237"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226237\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}