{"id":226142,"date":"2025-11-29T08:08:14","date_gmt":"2025-11-29T14:08:14","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/inhibiting-a-master-regulator-of-aging-regenerates-joint-cartilage-in-mice"},"modified":"2025-11-29T08:08:14","modified_gmt":"2025-11-29T14:08:14","slug":"inhibiting-a-master-regulator-of-aging-regenerates-joint-cartilage-in-mice","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/inhibiting-a-master-regulator-of-aging-regenerates-joint-cartilage-in-mice","title":{"rendered":"Inhibiting a master regulator of aging regenerates joint cartilage in mice"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/inhibiting-a-master-regulator-of-aging-regenerates-joint-cartilage-in-mice.jpg\"><\/a><\/p>\n<p>An injection that blocks the activity of a protein involved in aging reverses naturally occurring cartilage loss in the knee joints of old mice, a Stanford Medicine-led study has found. The treatment also prevented the development of arthritis after knee injuries mirroring the ACL tears often experienced by athletes or recreational exercisers. An oral version of the treatment is already in clinical trials with the goal of treating age-related muscle weakness.<\/p>\n<p>Samples of human tissue from knee replacement surgeries\u2014which include both the extracellular scaffolding, or matrix, in the joint as well as cartilage-generating chondrocyte cells\u2014also responded to the treatment by making new, functional cartilage.<\/p>\n<p>The study results suggest it may be possible to regenerate cartilage lost to aging or arthritis with an oral drug or local injection, rendering knee and hip replacement unnecessary.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An injection that blocks the activity of a protein involved in aging reverses naturally occurring cartilage loss in the knee joints of old mice, a Stanford Medicine-led study has found. The treatment also prevented the development of arthritis after knee injuries mirroring the ACL tears often experienced by athletes or recreational exercisers. An oral version [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,269],"tags":[],"class_list":["post-226142","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-life-extension"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226142"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226142\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}