{"id":226021,"date":"2025-11-27T04:05:00","date_gmt":"2025-11-27T10:05:00","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/first-in-human-trial-of-crispr-gene-editing-therapy-safely-lowered-cholesterol-triglycerides"},"modified":"2025-11-27T04:05:00","modified_gmt":"2025-11-27T10:05:00","slug":"first-in-human-trial-of-crispr-gene-editing-therapy-safely-lowered-cholesterol-triglycerides","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/first-in-human-trial-of-crispr-gene-editing-therapy-safely-lowered-cholesterol-triglycerides","title":{"rendered":"First-in-human trial of CRISPR gene-editing therapy safely lowered cholesterol, triglycerides"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/first-in-human-trial-of-crispr-gene-editing-therapy-safely-lowered-cholesterol-triglycerides2.jpg\"><\/a><\/p>\n<p>Research Highlights: In a Phase 1, first-in-human trial, a one-time infusion of an investigational CRISPR-Cas9 therapy targeting angiopoietin-like protein 3 (ANGPTL3) was safe and reduced LDL cholesterol by nearly 50% and reduced triglycerides by\u2026<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research Highlights: In a Phase 1, first-in-human trial, a one-time infusion of an investigational CRISPR-Cas9 therapy targeting angiopoietin-like protein 3 (ANGPTL3) was safe and reduced LDL cholesterol by nearly 50% and reduced triglycerides by\u2026<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-226021","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226021","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=226021"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/226021\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=226021"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=226021"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=226021"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}