{"id":225969,"date":"2025-11-26T17:14:50","date_gmt":"2025-11-26T23:14:50","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/prevention-and-reversal-of-hypertension%e2%80%90induced-coronary-microvascular-dysfunction-by-a-plant%e2%80%90based-diet"},"modified":"2025-11-26T17:14:50","modified_gmt":"2025-11-26T23:14:50","slug":"prevention-and-reversal-of-hypertension%e2%80%90induced-coronary-microvascular-dysfunction-by-a-plant%e2%80%90based-diet","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/prevention-and-reversal-of-hypertension%e2%80%90induced-coronary-microvascular-dysfunction-by-a-plant%e2%80%90based-diet","title":{"rendered":"Prevention and Reversal of Hypertension\u2010Induced Coronary Microvascular Dysfunction by a Plant\u2010Based Diet"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/prevention-and-reversal-of-hypertensione28090induced-coronary-microvascular-dysfunction-by-a-plante28090based-diet2.jpg\"><\/a><\/p>\n<p>Rac1 inhibition prevents axonal cytoskeleton dysfunction in transthyretin amyloid polyneuropathy.<\/p>\n<hr>\n<p>Magalh\u00e3es et al. reveal that Rac1 hyperactivation disrupts axonal cytoskeleton and transport in a mouse model of transthyretin amyloid polyneuropathy. They show that Rac1 inhibition prevents axonal degeneration and identify a patient-associated <i>RACGAP1<\/i> variant suggesting a neuroprotective role for Rac1 inactivation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rac1 inhibition prevents axonal cytoskeleton dysfunction in transthyretin amyloid polyneuropathy. Magalh\u00e3es et al. reveal that Rac1 hyperactivation disrupts axonal cytoskeleton and transport in a mouse model of transthyretin amyloid polyneuropathy. They show that Rac1 inhibition prevents axonal degeneration and identify a patient-associated RACGAP1 variant suggesting a neuroprotective role for Rac1 inactivation.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-225969","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225969","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=225969"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225969\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=225969"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=225969"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=225969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}