{"id":225831,"date":"2025-11-25T01:24:53","date_gmt":"2025-11-25T07:24:53","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/hidden-brain-energy-leak-links-stress-to-depression-and-anxiety"},"modified":"2025-11-25T01:24:53","modified_gmt":"2025-11-25T07:24:53","slug":"hidden-brain-energy-leak-links-stress-to-depression-and-anxiety","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/hidden-brain-energy-leak-links-stress-to-depression-and-anxiety","title":{"rendered":"Hidden Brain Energy Leak Links Stress to Depression and Anxiety"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/hidden-brain-energy-leak-links-stress-to-depression-and-anxiety.jpg\"><\/a><\/p>\n<p>Scientists found that reduced ATP signaling in the hippocampus can trigger both depression and anxiety in mice.<\/p>\n<p>Lower ATP levels and a drop in connexin 43 expression appeared to make stressed animals more vulnerable. Manipulating this protein alone was enough to produce mood-related symptoms, while restoring it reversed them.<\/p>\n<p>ATP Signaling and Mood Disorders.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists found that reduced ATP signaling in the hippocampus can trigger both depression and anxiety in mice. Lower ATP levels and a drop in connexin 43 expression appeared to make stressed animals more vulnerable. Manipulating this protein alone was enough to produce mood-related symptoms, while restoring it reversed them. ATP Signaling and Mood Disorders.<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-225831","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=225831"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225831\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=225831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=225831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=225831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}