{"id":225682,"date":"2025-11-22T12:16:38","date_gmt":"2025-11-22T18:16:38","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/an-excitatory-circuit-in-the-ventrolateral-periaqueductal-gray-drives-hypometabolic-state-during-acute-systemic-inflammation"},"modified":"2025-11-22T12:16:38","modified_gmt":"2025-11-22T18:16:38","slug":"an-excitatory-circuit-in-the-ventrolateral-periaqueductal-gray-drives-hypometabolic-state-during-acute-systemic-inflammation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/an-excitatory-circuit-in-the-ventrolateral-periaqueductal-gray-drives-hypometabolic-state-during-acute-systemic-inflammation","title":{"rendered":"An excitatory circuit in the ventrolateral periaqueductal gray drives hypometabolic state during acute systemic inflammation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/an-excitatory-circuit-in-the-ventrolateral-periaqueductal-gray-drives-hypometabolic-state-during-acute-systemic-inflammation2.jpg\"><\/a><\/p>\n<p>Xie et al. demonstrate that systemic inflammation activates a subset of glutamatergic neurons in the ventrolateral periaqueductal gray (vlPAG). Manipulating these vlPAG glutamatergic neurons and their projections to the nucleus tractus solitarius modulates inflammation-induced sickness behaviors and hypometabolic states, including hypothermia, cardiovascular depression, reduced locomotion, and appetite suppression.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xie et al. demonstrate that systemic inflammation activates a subset of glutamatergic neurons in the ventrolateral periaqueductal gray (vlPAG). Manipulating these vlPAG glutamatergic neurons and their projections to the nucleus tractus solitarius modulates inflammation-induced sickness behaviors and hypometabolic states, including hypothermia, cardiovascular depression, reduced locomotion, and appetite suppression.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[47],"tags":[],"class_list":["post-225682","post","type-post","status-publish","format-standard","hentry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225682","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=225682"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225682\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=225682"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=225682"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=225682"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}