{"id":225567,"date":"2025-11-21T02:03:30","date_gmt":"2025-11-21T08:03:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/new-on-switch-for-pain-signaling-pathway-could-lead-to-safer-treatment-and-relief"},"modified":"2025-11-21T02:03:30","modified_gmt":"2025-11-21T08:03:30","slug":"new-on-switch-for-pain-signaling-pathway-could-lead-to-safer-treatment-and-relief","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/new-on-switch-for-pain-signaling-pathway-could-lead-to-safer-treatment-and-relief","title":{"rendered":"New on-switch for pain signaling pathway could lead to safer treatment and relief"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-on-switch-for-pain-signaling-pathway-could-lead-to-safer-treatment-and-relief.jpg\"><\/a><\/p>\n<p>Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead to safer, more effective treatments.<\/p>\n<p>The study, co-led by Matthew Dalva, director of the Tulane Brain Institute and professor of cell and <a href=\"https:\/\/medicalxpress.com\/tags\/molecular+biology\/\" rel=\"tag\" class=\"\">molecular biology<\/a> in the School of <i>Science<\/i> and Engineering and Ted Price at the University of Texas at Dallas, reveals that neurons can release an enzyme outside the cell that switches on pain signaling after injury. The work, <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adp1007\" target=\"_blank\">published<\/a> in <i>Science<\/i>, offers new insight into how <a href=\"https:\/\/medicalxpress.com\/tags\/brain+cells\/\" rel=\"tag\" class=\"\">brain cells<\/a> strengthen their connections during learning and memory.<\/p>\n<p>\u201cThis finding changes our fundamental understanding of how neurons communicate,\u201d Dalva said. \u201cWe\u2019ve discovered that an enzyme released by neurons can modify proteins on the outside of other cells to turn on pain signaling\u2014without affecting normal movement or sensation.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead to safer, more effective treatments. The study, co-led by Matthew Dalva, director of the Tulane Brain Institute and professor of cell and molecular biology in [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,47],"tags":[],"class_list":["post-225567","post","type-post","status-publish","format-standard","hentry","category-biological","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=225567"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225567\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=225567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=225567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=225567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}