{"id":225297,"date":"2025-11-18T01:06:25","date_gmt":"2025-11-18T07:06:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/crispr-breakthrough-reverses-chemotherapy-resistance-in-lung-cancer"},"modified":"2025-11-18T01:06:25","modified_gmt":"2025-11-18T07:06:25","slug":"crispr-breakthrough-reverses-chemotherapy-resistance-in-lung-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/crispr-breakthrough-reverses-chemotherapy-resistance-in-lung-cancer","title":{"rendered":"CRISPR breakthrough reverses chemotherapy resistance in lung cancer"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/crispr-breakthrough-reverses-chemotherapy-resistance-in-lung-cancer.jpg\"><\/a><\/p>\n<p>In a major step forward for cancer care, researchers at ChristianaCare\u2019s Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach restores drug sensitivity and slows tumor growth. The findings are <a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950329925001481\" target=\"_blank\">published<\/a> in the journal Molecular Therapy Oncology.<\/p>\n<p>This breakthrough stems from more than a decade of research by the Gene Editing Institute into the NRF2 gene, a known driver of treatment resistance. The results were consistent across multiple in vitro studies using human lung cancer cell lines and in vivo animal models.<\/p>\n<p>\u201cWe\u2019ve seen compelling evidence at every stage of research,\u201d said Kelly Banas, Ph.D., lead author of the study and associate director of research at the Gene Editing Institute. \u201cIt\u2019s a strong foundation for taking the next step toward clinical trials.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a major step forward for cancer care, researchers at ChristianaCare\u2019s Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer. The approach restores drug sensitivity and slows tumor growth. The findings are published in the journal Molecular Therapy Oncology. This breakthrough stems from more [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11],"tags":[],"class_list":["post-225297","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=225297"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225297\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=225297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=225297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=225297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}