{"id":225296,"date":"2025-11-18T01:05:40","date_gmt":"2025-11-18T07:05:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/gene-switch-reverses-alzheimers-risk-in-experimental-model"},"modified":"2025-11-18T01:05:40","modified_gmt":"2025-11-18T07:05:40","slug":"gene-switch-reverses-alzheimers-risk-in-experimental-model","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/gene-switch-reverses-alzheimers-risk-in-experimental-model","title":{"rendered":"Gene \u2018switch\u2019 reverses Alzheimer\u2019s risk in experimental model"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/gene-switch-reverses-alzheimers-risk-in-experimental-model2.jpg\"><\/a><\/p>\n<p>University of Kentucky researchers have developed a new experimental model that could point the way toward more effective Alzheimer\u2019s disease treatments by targeting one of the brain\u2019s most important genes for risk and resilience.<\/p>\n<p>The study, <a href=\"https:\/\/www.nature.com\/articles\/s41593-025-02094-y\" target=\"_blank\">published in <i>Nature Neuroscience<\/i><\/a>, focuses on apolipoprotein E (APOE), a gene long known to play a major role in Alzheimer\u2019s disease. The team created a first-of-its-kind mouse model that allows scientists to \u201cflip a switch,\u201d changing the high-risk version of the gene (APOE4) to the protective form (APOE2) in adult animals.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>University of Kentucky researchers have developed a new experimental model that could point the way toward more effective Alzheimer\u2019s disease treatments by targeting one of the brain\u2019s most important genes for risk and resilience. The study, published in Nature Neuroscience, focuses on apolipoprotein E (APOE), a gene long known to play a major role in [\u2026]<\/p>\n","protected":false},"author":511,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-225296","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/511"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=225296"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225296\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=225296"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=225296"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=225296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}