{"id":225172,"date":"2025-11-15T16:05:51","date_gmt":"2025-11-15T22:05:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/nad-rescues-mouse-tauopathy-by-fixing-alternative-splicing"},"modified":"2025-11-15T16:05:51","modified_gmt":"2025-11-15T22:05:51","slug":"nad-rescues-mouse-tauopathy-by-fixing-alternative-splicing","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/nad-rescues-mouse-tauopathy-by-fixing-alternative-splicing","title":{"rendered":"NAD+ Rescues Mouse Tauopathy by Fixing Alternative Splicing"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nad-rescues-mouse-tauopathy-by-fixing-alternative-splicing2.jpg\"><\/a><\/p>\n<p>A new study reveals <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41202143\/\">a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer\u2019s<\/a> [1].<\/p>\n<p><b><b>Which way to splice it?<\/b><\/b><\/p>\n<p>Not every part of a DNA sequence gets translated into a protein. Each sequence consists of exons, which are included in the final RNA transcript, and introns, which are thrown away.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study reveals a surprising mechanism that might be behind the beneficial effects of NAD+ in preclinical models of Alzheimer\u2019s [1]. Which way to splice it? Not every part of a DNA sequence gets translated into a protein. Each sequence consists of exons, which are included in the final RNA transcript, and introns, which [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-225172","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=225172"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225172\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=225172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=225172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=225172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}