{"id":225091,"date":"2025-11-14T12:04:40","date_gmt":"2025-11-14T18:04:40","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/reversing-fibrosis-new-research-provides-insight-for-novel-therapies"},"modified":"2025-11-14T12:04:40","modified_gmt":"2025-11-14T18:04:40","slug":"reversing-fibrosis-new-research-provides-insight-for-novel-therapies","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/reversing-fibrosis-new-research-provides-insight-for-novel-therapies","title":{"rendered":"Reversing fibrosis: New research provides insight for novel therapies"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/reversing-fibrosis-new-research-provides-insight-for-novel-therapies2.jpg\"><\/a><\/p>\n<p>Yale School of Medicine (YSM) researchers have made key breakthroughs in understanding how to treat fibrotic diseases such as scleroderma and graft-versus-host disease.<\/p>\n<p>Fibrotic diseases are a group of conditions\u2014often autoimmune\u2014characterized by excessive tissue scarring. They can drastically hinder patients\u2019 quality of life, and in some cases, they can be life-threatening\u2014 <a href=\"https:\/\/medicalxpress.com\/tags\/fibrosis\/\" rel=\"tag\" class=\"\">fibrosis<\/a> contributes to approximately <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12467191\/#:~:text=Fibrosis%20is%20a%20progressive%20pathological, more%20recent%20and%20detailed%20data.\" target=\"_blank\">45% of all deaths<\/a> in developed nations. However, there are no effective treatments.<\/p>\n<p>Now, in a <a href=\"https:\/\/ashpublications.org\/blood\/article\/doi\/10.1182\/blood.2025029836\/547298\/Sclerotic-GVHD-and-Scleroderma-Share-Dysregulated\" target=\"_blank\">study published in <i>Blood<\/i><\/a>, researchers have developed a monoclonal antibody that is showing promise as a new therapy for patients. And in a <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-64648-9\" target=\"_blank\"><i>Nature Communications<\/i> study<\/a>, the same team discovered a signaling pathway that may be mediating fibrosis and could be a target for future therapies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Yale School of Medicine (YSM) researchers have made key breakthroughs in understanding how to treat fibrotic diseases such as scleroderma and graft-versus-host disease. Fibrotic diseases are a group of conditions\u2014often autoimmune\u2014characterized by excessive tissue scarring. They can drastically hinder patients\u2019 quality of life, and in some cases, they can be life-threatening\u2014 fibrosis contributes to approximately [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1522],"tags":[],"class_list":["post-225091","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-innovation"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=225091"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225091\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=225091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=225091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=225091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}