{"id":225086,"date":"2025-11-14T01:26:58","date_gmt":"2025-11-14T07:26:58","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/researchers-reveal-intricate-control-system-for-key-immune-gene"},"modified":"2025-11-14T01:26:58","modified_gmt":"2025-11-14T07:26:58","slug":"researchers-reveal-intricate-control-system-for-key-immune-gene","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/researchers-reveal-intricate-control-system-for-key-immune-gene","title":{"rendered":"Researchers reveal intricate control system for key immune gene"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/researchers-reveal-intricate-control-system-for-key-immune-gene2.jpg\"><\/a><\/p>\n<p>The immune system faces a delicate balancing act: It must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body\u2019s own tissues.<\/p>\n<p>More than two decades ago, researchers identified a gene called FOXP3 as playing a critical role in maintaining this balance and preventing autoimmune disease\u2014work that garnered this year\u2019s Nobel Prize in Physiology or Medicine.<\/p>\n<p>Now, scientists at Gladstone Institutes and UC San Francisco (UCSF) have mapped the intricate network of genetic switches that <a href=\"https:\/\/medicalxpress.com\/tags\/immune+cells\/\" rel=\"tag\" class=\"\">immune cells<\/a> use to fine-tune levels of FOXP3. Their findings, <a href=\"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761325004741\" target=\"_blank\">published<\/a> in <i>Immunity<\/i>, have important implications for developing immune therapies and address a long-standing mystery about why this gene behaves differently in humans than in mice.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The immune system faces a delicate balancing act: It must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body\u2019s own tissues. More than two decades ago, researchers identified a gene called FOXP3 as playing a critical role in maintaining this balance and preventing autoimmune disease\u2014work that garnered this [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-225086","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=225086"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/225086\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=225086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=225086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=225086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}