{"id":224942,"date":"2025-11-12T05:03:55","date_gmt":"2025-11-12T11:03:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/nuclear-lamin-guided-plastic-positioning-and-folding-of-the-human-genome"},"modified":"2025-11-12T05:03:55","modified_gmt":"2025-11-12T11:03:55","slug":"nuclear-lamin-guided-plastic-positioning-and-folding-of-the-human-genome","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/nuclear-lamin-guided-plastic-positioning-and-folding-of-the-human-genome","title":{"rendered":"Nuclear-lamin-guided plastic positioning and folding of the human genome"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nuclear-lamin-guided-plastic-positioning-and-folding-of-the-human-genome2.jpg\"><\/a><\/p>\n<p>Wang et al. systematically depicted the lamins-guided 3D epigenome in human stem cells and demonstrated that lamins not only serve as key regulators of chromatin-NL tethering and large-scale genome organization but also are essential for the spatial positioning and clustering of nuclear speckle through direct interactions within the nuclear interior.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wang et al. systematically depicted the lamins-guided 3D epigenome in human stem cells and demonstrated that lamins not only serve as key regulators of chromatin-NL tethering and large-scale genome organization but also are essential for the spatial positioning and clustering of nuclear speckle through direct interactions within the nuclear interior.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-224942","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224942","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224942"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224942\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}