{"id":224925,"date":"2025-11-12T01:17:51","date_gmt":"2025-11-12T07:17:51","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/nonsurgical-treatment-shows-promise-for-targeted-seizure-control"},"modified":"2025-11-12T01:17:51","modified_gmt":"2025-11-12T07:17:51","slug":"nonsurgical-treatment-shows-promise-for-targeted-seizure-control","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/nonsurgical-treatment-shows-promise-for-targeted-seizure-control","title":{"rendered":"Nonsurgical treatment shows promise for targeted seizure control"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/nonsurgical-treatment-shows-promise-for-targeted-seizure-control2.jpg\"><\/a><\/p>\n<p>Rice University bioengineers have demonstrated a nonsurgical way to quiet a seizure-relevant brain circuit in an animal model. The team used low-intensity focused ultrasound to briefly open the blood-brain barrier (BBB) in the hippocampus, delivered an engineered gene therapy only to that region and later flipped an on-demand \u201cdimmer switch\u201d with an oral drug.<\/p>\n<p>The research shows that a one-time, targeted procedure can modulate a specific brain region without impacting off-target areas of the brain. It is <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acschemneuro.5c00404\" target=\"_blank\">published<\/a> in and featured on the cover of ACS Chemical Neuroscience.<\/p>\n<p>\u201cMany <a href=\"https:\/\/medicalxpress.com\/tags\/neurological+diseases\/\" rel=\"tag\" class=\"\">neurological diseases<\/a> are driven by hyperactive cells at a particular location in the brain,\u201d said study lead Jerzy Szablowski, assistant professor of bioengineering and a member of the Rice Neuroengineering Initiative. \u201cOur approach aims the therapy where it is needed and lets you control it when you need it, without surgery and without a permanent implant.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Rice University bioengineers have demonstrated a nonsurgical way to quiet a seizure-relevant brain circuit in an animal model. The team used low-intensity focused ultrasound to briefly open the blood-brain barrier (BBB) in the hippocampus, delivered an engineered gene therapy only to that region and later flipped an on-demand \u201cdimmer switch\u201d with an oral drug. The [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,19,47],"tags":[],"class_list":["post-224925","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-chemistry","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224925"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224925\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}