{"id":224830,"date":"2025-11-10T08:14:23","date_gmt":"2025-11-10T14:14:23","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/antibody-therapy-foils-pancreatic-cancers-sugar-based-disguise-to-reawaken-immune-system"},"modified":"2025-11-10T08:14:23","modified_gmt":"2025-11-10T14:14:23","slug":"antibody-therapy-foils-pancreatic-cancers-sugar-based-disguise-to-reawaken-immune-system","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/antibody-therapy-foils-pancreatic-cancers-sugar-based-disguise-to-reawaken-immune-system","title":{"rendered":"Antibody therapy foils pancreatic cancer\u2019s sugar-based disguise to reawaken immune system"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/antibody-therapy-foils-pancreatic-cancers-sugar-based-disguise-to-reawaken-immune-system2.jpg\"><\/a><\/p>\n<p>Pancreatic cancer is notoriously hard to treat and often resists the most advanced immunotherapies. Northwestern Medicine scientists have uncovered a novel explanation for that resistance: Pancreatic tumors use a sugar-based disguise to hide from the immune system. The scientists also created an antibody therapy that blocks the sugar-mediated \u201cdon\u2019t-attack\u201d signal.<\/p>\n<p>For the first time, the team identified how this sugar trick works and showed that blocking it with a monoclonal antibody reawakens immune cells to attack cancer cells in preclinical mouse models.<\/p>\n<p>\u201cIt took our team about six years to uncover this novel mechanism, develop the right antibodies and test them,\u201d said study senior author Mohamed Abdel-Mohsen, associate professor of medicine in the division of infectious diseases at Northwestern University Feinberg School of Medicine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pancreatic cancer is notoriously hard to treat and often resists the most advanced immunotherapies. Northwestern Medicine scientists have uncovered a novel explanation for that resistance: Pancreatic tumors use a sugar-based disguise to hide from the immune system. The scientists also created an antibody therapy that blocks the sugar-mediated \u201cdon\u2019t-attack\u201d signal. For the first time, the [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-224830","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224830","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224830"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224830\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224830"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224830"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224830"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}