{"id":224735,"date":"2025-11-08T00:14:30","date_gmt":"2025-11-08T06:14:30","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/gut-to-brain-signaling-restricts-post-illness-protein-appetite-researchers-discover"},"modified":"2025-11-08T00:14:30","modified_gmt":"2025-11-08T06:14:30","slug":"gut-to-brain-signaling-restricts-post-illness-protein-appetite-researchers-discover","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/gut-to-brain-signaling-restricts-post-illness-protein-appetite-researchers-discover","title":{"rendered":"Gut-to-brain signaling restricts post-illness protein appetite, researchers discover"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/La7A2YlSnOg?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>When we get sick, with the flu, say, or pneumonia, there can be a period where the major symptoms of our illness have resolved but we still just don\u2019t feel great.<\/p>\n<p>\u201cWhile this is common, there\u2019s no real way to quantify what\u2019s going on,\u201d says Nikolai Jaschke, MD, Ph.D., who recently completed a postdoctoral fellowship at Yale School of Medicine (YSM) in the lab of Andrew Wang, MD, Ph.D., associate professor of internal medicine (rheumatology). \u201cAnd unfortunately, we lack therapeutic tools to support people in this state.\u201d<\/p>\n<p>Jaschke noticed this while taking care of patients recovering from acute illnesses and, when he joined Wang\u2019s lab, he began studying what was happening in the body during recovery. Through this work, Jaschke, Wang, and their colleagues uncovered a gut-to-brain signaling pathway in <a href=\"https:\/\/medicalxpress.com\/tags\/mice\/\" rel=\"tag\" class=\"\">mice<\/a> that restricts appetite\u2014specifically for protein\u2014during recovery. They <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(25)01134-1\" target=\"_blank\">published<\/a> their findings on Nov. 4 in <i>Cell<\/i>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>When we get sick, with the flu, say, or pneumonia, there can be a period where the major symptoms of our illness have resolved but we still just don\u2019t feel great. \u201cWhile this is common, there\u2019s no real way to quantify what\u2019s going on,\u201d says Nikolai Jaschke, MD, Ph.D., who recently completed a postdoctoral fellowship [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-224735","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224735","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224735"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224735\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224735"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224735"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}