{"id":224711,"date":"2025-11-07T16:10:09","date_gmt":"2025-11-07T22:10:09","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/overcoming-resistance-to-immune-checkpoint-inhibitors-remains-a-major-objective-in-cancer"},"modified":"2025-11-07T16:10:09","modified_gmt":"2025-11-07T22:10:09","slug":"overcoming-resistance-to-immune-checkpoint-inhibitors-remains-a-major-objective-in-cancer","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/overcoming-resistance-to-immune-checkpoint-inhibitors-remains-a-major-objective-in-cancer","title":{"rendered":"Overcoming resistance to immune checkpoint inhibitors remains a major objective in cancer"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/overcoming-resistance-to-immune-checkpoint-inhibitors-remains-a-major-objective-in-cancer.jpg\"><\/a><\/p>\n<p>Here, Richard Bucala &amp; team show combined anti-MIF and anti\u2013PD-1 reduces tumor growth and improves survival in melanoma and colorectal cancer mouse models:<\/p>\n<p>The figure shows tumor regions of necrosis, immune infiltration, and reduced tumor volume in mice treated with MIF and PD-1.<\/p>\n<hr>\n<p>\n<sup>1<\/sup>Yale Cancer Center, Department of Internal Medicine, and.<\/p>\n<p><sup>2<\/sup>Section of Rheumatology, Allergy &amp; <i>Immunology<\/i>, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.<\/p>\n<p><sup>3<\/sup>Department of Medicine, Trinity College Dublin, Dublin, Ireland.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Here, Richard Bucala &amp; team show combined anti-MIF and anti\u2013PD-1 reduces tumor growth and improves survival in melanoma and colorectal cancer mouse models: The figure shows tumor regions of necrosis, immune infiltration, and reduced tumor volume in mice treated with MIF and PD-1. 1Yale Cancer Center, Department of Internal Medicine, and. 2Section of Rheumatology, Allergy [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-224711","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224711"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224711\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}