{"id":224452,"date":"2025-11-03T20:10:43","date_gmt":"2025-11-04T02:10:43","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/turning-on-an-immune-pathway-in-tumors-could-lead-to-their-destruction"},"modified":"2025-11-03T20:10:43","modified_gmt":"2025-11-04T02:10:43","slug":"turning-on-an-immune-pathway-in-tumors-could-lead-to-their-destruction","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/turning-on-an-immune-pathway-in-tumors-could-lead-to-their-destruction","title":{"rendered":"Turning on an immune pathway in tumors could lead to their destruction"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/turning-on-an-immune-pathway-in-tumors-could-lead-to-their-destruction2.jpg\"><\/a><\/p>\n<p>Activating this <a href=\"https:\/\/medicalxpress.com\/tags\/signaling+pathway\/\" rel=\"tag\" class=\"\">signaling pathway<\/a>, known as the cGAS-STING pathway, worked even better when combined with existing immunotherapy drugs known as checkpoint blockade inhibitors, in a study of mice. That dual treatment was successfully able to control tumor growth.<\/p>\n<p>The researchers turned on the cGAS-STING pathway in immune cells using messenger RNA delivered to <a href=\"https:\/\/medicalxpress.com\/tags\/cancer+cells\/\" rel=\"tag\" class=\"\">cancer cells<\/a>. This approach may avoid the <a href=\"https:\/\/medicalxpress.com\/tags\/side+effects\/\" rel=\"tag\" class=\"\">side effects<\/a> of delivering large doses of a STING activator, and takes advantage of a natural process in the body. This could make it easier to develop a treatment for use in patients, the researchers say.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Activating this signaling pathway, known as the cGAS-STING pathway, worked even better when combined with existing immunotherapy drugs known as checkpoint blockade inhibitors, in a study of mice. That dual treatment was successfully able to control tumor growth. The researchers turned on the cGAS-STING pathway in immune cells using messenger RNA delivered to cancer cells. [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-224452","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224452"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224452\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}