{"id":224432,"date":"2025-11-03T13:12:57","date_gmt":"2025-11-03T19:12:57","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/how-a-tiny-rna-molecule-in-the-kidney-triggers-a-deadly-autoimmune-disease"},"modified":"2025-11-03T13:12:57","modified_gmt":"2025-11-03T19:12:57","slug":"how-a-tiny-rna-molecule-in-the-kidney-triggers-a-deadly-autoimmune-disease","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/how-a-tiny-rna-molecule-in-the-kidney-triggers-a-deadly-autoimmune-disease","title":{"rendered":"How a tiny RNA molecule in the kidney triggers a deadly autoimmune disease"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-a-tiny-rna-molecule-in-the-kidney-triggers-a-deadly-autoimmune-disease2.jpg\"><\/a><\/p>\n<p>Researchers at the University Hospital Bonn (UKB) and the University of Bonn have discovered how a small, naturally occurring RNA molecule in the kidney activates a mutated immune receptor, triggering a chain reaction.<\/p>\n<p>In cooperation with Nanyang Technological University Singapore and the University Hospital W\u00fcrzburg, among others, the study provides an explanation of how a <a href=\"https:\/\/medicalxpress.com\/tags\/point+mutation\/\" rel=\"tag\" class=\"\">point mutation<\/a> in the immune receptor RIG-I transforms the body\u2019s defense system into a self-destructive force and causes severe organ-specific autoimmune diseases.<\/p>\n<p>The results have been <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciimmunol.adx1135\" target=\"_blank\">published<\/a> in the journal Science Immunology.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University Hospital Bonn (UKB) and the University of Bonn have discovered how a small, naturally occurring RNA molecule in the kidney activates a mutated immune receptor, triggering a chain reaction. In cooperation with Nanyang Technological University Singapore and the University Hospital W\u00fcrzburg, among others, the study provides an explanation of how a [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-224432","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224432"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224432\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}