{"id":224424,"date":"2025-11-03T08:06:19","date_gmt":"2025-11-03T14:06:19","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/11\/holographic-optogenetics-could-enable-faster-brain-mapping-for-new-discoveries"},"modified":"2025-11-03T08:06:19","modified_gmt":"2025-11-03T14:06:19","slug":"holographic-optogenetics-could-enable-faster-brain-mapping-for-new-discoveries","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/11\/holographic-optogenetics-could-enable-faster-brain-mapping-for-new-discoveries","title":{"rendered":"Holographic optogenetics could enable faster brain mapping for new discoveries"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/holographic-optogenetics-could-enable-faster-brain-mapping-for-new-discoveries3.jpg\"><\/a><\/p>\n<p>Recent technological advances have opened new possibilities for neuroscience research, allowing researchers to map the brain\u2019s structure and synaptic connectivity (i.e., the junctions via which neurons communicate with each other) with increasing precision.<\/p>\n<p>Despite these developments, most widely employed methods to image synaptic connectivity are slow and fail to precisely record changes in the connections between <a href=\"https:\/\/medicalxpress.com\/tags\/neurons\/\" rel=\"tag\" class=\"\">neurons<\/a> in vivo, or in other words, while animals are awake and engaging in specific activities.<\/p>\n<p>Two different research groups, one based at Columbia University and UC Berkeley, and the other at the Vision Institute of Sorbonne University in Paris, introduced a promising approach to study synapses in vivo. Their proposed mapping strategies, outlined in two <i>Nature Neuroscience<\/i> papers, combine holographic optogenetics, a method to selectively and precisely stimulate or silence specific neuron populations, with <a href=\"https:\/\/medicalxpress.com\/tags\/computational+techniques\/\" rel=\"tag\" class=\"\">computational techniques<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recent technological advances have opened new possibilities for neuroscience research, allowing researchers to map the brain\u2019s structure and synaptic connectivity (i.e., the junctions via which neurons communicate with each other) with increasing precision. Despite these developments, most widely employed methods to image synaptic connectivity are slow and fail to precisely record changes in the connections [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1523,412,1965,47],"tags":[],"class_list":["post-224424","post","type-post","status-publish","format-standard","hentry","category-computing","category-genetics","category-mapping","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224424"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224424\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224424"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224424"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}