{"id":224309,"date":"2025-10-31T06:29:02","date_gmt":"2025-10-31T11:29:02","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/computationally-accelerated-organic-synthesis-optimal-ligand-prediction-for-generating-reactive-alkyl-ketone-radicals"},"modified":"2025-10-31T06:29:02","modified_gmt":"2025-10-31T11:29:02","slug":"computationally-accelerated-organic-synthesis-optimal-ligand-prediction-for-generating-reactive-alkyl-ketone-radicals","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/computationally-accelerated-organic-synthesis-optimal-ligand-prediction-for-generating-reactive-alkyl-ketone-radicals","title":{"rendered":"Computationally accelerated organic synthesis: Optimal ligand prediction for generating reactive alkyl ketone radicals"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/computationally-accelerated-organic-synthesis-optimal-ligand-prediction-for-generating-reactive-alkyl-ketone-radicals.jpg\"><\/a><\/p>\n<p>Because ketones are widespread in organic molecules, chemists are eager to develop new reactions that use them to form chemical bonds. One challenging reaction is the one-electron reduction of ketones to generate ketyl radicals.<\/p>\n<p>Ketyl radicals are reactive intermediates used in natural product synthesis and pharmaceutical chemistry; however, most methodologies are optimized for aryl <a href=\"https:\/\/phys.org\/tags\/ketones\/\" rel=\"tag\" class=\"\">ketones<\/a> while simple alkyl ketones remain challenging for chemists. Alkyl ketones are considerably more abundant but intrinsically more difficult to reduce than aryl ketones.<\/p>\n<p>To this end, a team of specialized organic chemists and computational chemists from WPI-ICReDD at Hokkaido University has developed a new catalytic method for generating alkyl ketyl radicals.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Because ketones are widespread in organic molecules, chemists are eager to develop new reactions that use them to form chemical bonds. One challenging reaction is the one-electron reduction of ketones to generate ketyl radicals. Ketyl radicals are reactive intermediates used in natural product synthesis and pharmaceutical chemistry; however, most methodologies are optimized for aryl ketones [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19,1523],"tags":[],"class_list":["post-224309","post","type-post","status-publish","format-standard","hentry","category-chemistry","category-computing"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224309","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224309"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224309\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224309"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224309"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}