{"id":224276,"date":"2025-10-30T22:04:21","date_gmt":"2025-10-31T03:04:21","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/brca2-research-reveals-a-novel-mechanism-behind-chemoresistance"},"modified":"2025-10-30T22:04:21","modified_gmt":"2025-10-31T03:04:21","slug":"brca2-research-reveals-a-novel-mechanism-behind-chemoresistance","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/brca2-research-reveals-a-novel-mechanism-behind-chemoresistance","title":{"rendered":"BRCA2 research reveals a novel mechanism behind chemoresistance"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/brca2-research-reveals-a-novel-mechanism-behind-chemoresistance3.jpg\"><\/a><\/p>\n<p>One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often limited.<\/p>\n<p>A research team led by Arnab Ray Chaudhuri at the Department of Molecular Genetics, Erasmus MC Cancer Institute has now uncovered a mechanism by which BRCA2-deficient tumors develop this resistance. The proteins BRCA2 and FIGNL1 appear to have a different function than previously assumed.<\/p>\n<p>\u201cThese findings change the paradigm of thought,\u201d says Ray Chaudhuri. The team also identified ways to reverse or prevent resistance.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often limited. A research team led by Arnab Ray Chaudhuri at the Department of Molecular Genetics, Erasmus MC Cancer Institute has now uncovered a mechanism by which BRCA2-deficient [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-224276","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224276"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224276\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}