{"id":224172,"date":"2025-10-28T17:09:29","date_gmt":"2025-10-28T22:09:29","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/drugs-approved-for-treating-pain-may-also-reduce-bone-cancer-growth"},"modified":"2025-10-28T17:09:29","modified_gmt":"2025-10-28T22:09:29","slug":"drugs-approved-for-treating-pain-may-also-reduce-bone-cancer-growth","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/drugs-approved-for-treating-pain-may-also-reduce-bone-cancer-growth","title":{"rendered":"Drugs approved for treating pain may also reduce bone cancer growth"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/drugs-approved-for-treating-pain-may-also-reduce-bone-cancer-growth.jpg\"><\/a><\/p>\n<p>Peripheral afferent neurons\u2014nerves that send signals from all areas of the body to the central nervous system (brain and spinal cord)\u2014are known to infiltrate and grow within malignant bone tumors called osteosarcomas, often accompanied by severe pain.<\/p>\n<p>In a study <a href=\"https:\/\/pnas.org\/doi\/10.1073\/pnas.2500161122\" target=\"_blank\">published<\/a> in <i>Proceedings of the National Academy of Sciences<\/i>, a multicenter research team led by Johns Hopkins Medicine reports that two analgesic drugs, bupivacaine and rimegepant, which are used to inhibit the formation and functioning of these neurons, not only relieve <a href=\"https:\/\/medicalxpress.com\/tags\/tumor\/\" rel=\"tag\" class=\"\">tumor<\/a>-associated pain in <a href=\"https:\/\/medicalxpress.com\/tags\/laboratory+mice\/\" rel=\"tag\" class=\"\">laboratory mice<\/a>, but also slow the unchecked growth of the cancer.<\/p>\n<p>\u201cOur findings suggest that these two medications\u2014already approved by the U.S. Food and Drug Administration [FDA] for relieving <a href=\"https:\/\/medicalxpress.com\/tags\/nerve+pain\/\" rel=\"tag\" class=\"\">nerve pain<\/a> [bupivacaine] and migraines [rimegepant]\u2014might one day be repurposed as anti-tumor therapies,\u201d says study lead author Sowmya Ramesh, Ph.D., a postdoctoral researcher in pathology at the Johns Hopkins University School of Medicine.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Peripheral afferent neurons\u2014nerves that send signals from all areas of the body to the central nervous system (brain and spinal cord)\u2014are known to infiltrate and grow within malignant bone tumors called osteosarcomas, often accompanied by severe pain. In a study published in Proceedings of the National Academy of Sciences, a multicenter research team led by [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-224172","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224172"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224172\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}