{"id":224085,"date":"2025-10-27T06:06:08","date_gmt":"2025-10-27T11:06:08","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/mosquito-saliva-may-hold-clues-to-fighting-chikungunya-inflammation"},"modified":"2025-10-27T06:06:08","modified_gmt":"2025-10-27T11:06:08","slug":"mosquito-saliva-may-hold-clues-to-fighting-chikungunya-inflammation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/mosquito-saliva-may-hold-clues-to-fighting-chikungunya-inflammation","title":{"rendered":"Mosquito saliva may hold clues to fighting chikungunya inflammation"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/mosquito-saliva-may-hold-clues-to-fighting-chikungunya-inflammation.jpg\"><\/a><\/p>\n<p>Scientists from the A*STAR Infectious Diseases Labs (A*STAR IDL) have uncovered a surprising mechanism showing how mosquito saliva can alter the human body\u2019s immune response during chikungunya virus (CHIKV) infection, contributing to Singapore\u2019s broader efforts to strengthen infectious disease preparedness.<\/p>\n<p>The research, <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-64468-x\" target=\"_blank\">published<\/a> in <i>Nature Communications<\/i>, reveals that sialokinin, a bioactive peptide in Aedes mosquito <a href=\"https:\/\/medicalxpress.com\/tags\/saliva\/\" rel=\"tag\" class=\"\">saliva<\/a>, binds to neurokinin receptors on <a href=\"https:\/\/medicalxpress.com\/tags\/immune+cells\/\" rel=\"tag\" class=\"\">immune cells<\/a> and suppresses monocyte activation, thereby reducing inflammation and facilitating early viral dissemination. These findings offer new insight into how <a href=\"https:\/\/medicalxpress.com\/tags\/mosquito+bites\/\" rel=\"tag\" class=\"\">mosquito bites<\/a> shape disease outcomes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists from the A*STAR Infectious Diseases Labs (A*STAR IDL) have uncovered a surprising mechanism showing how mosquito saliva can alter the human body\u2019s immune response during chikungunya virus (CHIKV) infection, contributing to Singapore\u2019s broader efforts to strengthen infectious disease preparedness. The research, published in Nature Communications, reveals that sialokinin, a bioactive peptide in Aedes mosquito [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-224085","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=224085"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/224085\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=224085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=224085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=224085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}