{"id":223718,"date":"2025-10-21T04:23:04","date_gmt":"2025-10-21T09:23:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/how-a-human-jumping-gene-targets-structured-dna-to-reshape-the-genome"},"modified":"2025-10-21T04:23:04","modified_gmt":"2025-10-21T09:23:04","slug":"how-a-human-jumping-gene-targets-structured-dna-to-reshape-the-genome","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/how-a-human-jumping-gene-targets-structured-dna-to-reshape-the-genome","title":{"rendered":"How a human \u2018jumping gene\u2019 targets structured DNA to reshape the genome"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/how-a-human-jumping-gene-targets-structured-dna-to-reshape-the-genome2.jpg\"><\/a><\/p>\n<p>Long interspersed nuclear element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human genome\u2014comprising about 17% of the genome. It is commonly called a \u201cjumping gene\u201d or \u201cretrotransposon\u201d because it can \u201cretrotranspose\u201d (move) from one genomic location to another.<\/p>\n<p>Researchers from the Institute of Biophysics of the Chinese Academy of <i>Science<\/i>s have now unveiled the molecular mechanisms that underlie L1\u2019s retrotransposition and integration into genomic DNA. Their study was <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adu3433\" target=\"_blank\">published<\/a> in <i>Science<\/i> on October 9.<\/p>\n<p>L1 is the only autonomously active retrotransposon in the <a href=\"https:\/\/phys.org\/tags\/human+genome\/\" rel=\"tag\" class=\"\">human genome<\/a> and serves as the primary vehicle for the mobilization of most other retrotransposons. Its retrotransposition process is mediated by the reverse transcriptase ORF2p through a mechanism known as target-primed reverse transcription (TPRT). Until now, the manner in which ORF2p recognizes DNA targets and mediates integration had remained unclear.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Long interspersed nuclear element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human genome\u2014comprising about 17% of the genome. It is commonly called a \u201cjumping gene\u201d or \u201cretrotransposon\u201d because it can \u201cretrotranspose\u201d (move) from one genomic location to another. Researchers from the Institute of Biophysics of the Chinese Academy of Sciences [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412,6],"tags":[],"class_list":["post-223718","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics","category-robotics-ai"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223718","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=223718"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223718\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=223718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=223718"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=223718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}