{"id":223658,"date":"2025-10-19T12:13:48","date_gmt":"2025-10-19T17:13:48","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/disease-associated-radial-glia-like-cells-with-epigenetically-dysregulated-interferon-response-in-ms"},"modified":"2025-10-19T12:13:48","modified_gmt":"2025-10-19T17:13:48","slug":"disease-associated-radial-glia-like-cells-with-epigenetically-dysregulated-interferon-response-in-ms","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/disease-associated-radial-glia-like-cells-with-epigenetically-dysregulated-interferon-response-in-ms","title":{"rendered":"Disease-associated radial glia-like cells with epigenetically dysregulated interferon response in MS"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/disease-associated-radial-glia-like-cells-with-epigenetically-dysregulated-interferon-response-in-ms2.jpg\"><\/a><\/p>\n<p>Li et al. report that <i><i>Edwardsiella<\/i> <i>piscicida<\/i><\/i> employs HigA, an anti-toxin protein, to facilitate the diversion of tryptophan metabolism to the kynurenine pathway, rather than the serotonin pathway, by directly activating IDO1 in a T6SS-dependent manner as a cross-kingdom effector. The serotonin-level fluctuation modulates host intestinal histological damage and bacterial infection.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Li et al. report that Edwardsiella piscicida employs HigA, an anti-toxin protein, to facilitate the diversion of tryptophan metabolism to the kynurenine pathway, rather than the serotonin pathway, by directly activating IDO1 in a T6SS-dependent manner as a cross-kingdom effector. The serotonin-level fluctuation modulates host intestinal histological damage and bacterial infection.<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,412],"tags":[],"class_list":["post-223658","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-genetics"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=223658"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223658\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=223658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=223658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=223658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}