{"id":223627,"date":"2025-10-18T08:06:33","date_gmt":"2025-10-18T13:06:33","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/leukemia-cells-evade-treatment-by-reshaping-their-mitochondria-researchers-discover"},"modified":"2025-10-18T08:06:33","modified_gmt":"2025-10-18T13:06:33","slug":"leukemia-cells-evade-treatment-by-reshaping-their-mitochondria-researchers-discover","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/leukemia-cells-evade-treatment-by-reshaping-their-mitochondria-researchers-discover","title":{"rendered":"Leukemia cells evade treatment by reshaping their mitochondria, researchers discover"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/leukemia-cells-evade-treatment-by-reshaping-their-mitochondria-researchers-discover.jpg\"><\/a><\/p>\n<p>Researchers from Rutgers Health and other institutions have discovered why a powerful leukemia drug eventually fails in most patients\u2014and found a potential way to overcome that resistance.<\/p>\n<p>Team members identified a protein that lets <a href=\"https:\/\/medicalxpress.com\/tags\/cancer+cells\/\" rel=\"tag\" class=\"\">cancer cells<\/a> reshape their energy-producing mitochondria in ways that protect them from venetoclax (brand name, Venclexta), a <a href=\"https:\/\/medicalxpress.com\/tags\/standard+treatment\/\" rel=\"tag\" class=\"\">standard treatment<\/a> for acute myeloid leukemia that often loses effectiveness after prolonged use.<\/p>\n<p>Blocking that protein with experimental compounds in mice with human acute myeloid leukemia restored the drug\u2019s effectiveness and prolonged survival.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from Rutgers Health and other institutions have discovered why a powerful leukemia drug eventually fails in most patients\u2014and found a potential way to overcome that resistance. Team members identified a protein that lets cancer cells reshape their energy-producing mitochondria in ways that protect them from venetoclax (brand name, Venclexta), a standard treatment for acute [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,1495],"tags":[],"class_list":["post-223627","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-health"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=223627"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223627\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=223627"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=223627"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=223627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}