{"id":223626,"date":"2025-10-18T08:05:25","date_gmt":"2025-10-18T13:05:25","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/lab-grown-brains-with-all-major-cell-types-support-next-generation-therapy-research"},"modified":"2025-10-18T08:05:25","modified_gmt":"2025-10-18T13:05:25","slug":"lab-grown-brains-with-all-major-cell-types-support-next-generation-therapy-research","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/lab-grown-brains-with-all-major-cell-types-support-next-generation-therapy-research","title":{"rendered":"Lab-grown brains with all major cell types support next-generation therapy research"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/lab-grown-brains-with-all-major-cell-types-support-next-generation-therapy-research2.jpg\"><\/a><\/p>\n<p>A new 3D human brain tissue platform developed by MIT researchers is the first to integrate all major brain cell types, including neurons, glial cells and the vasculature into a single culture. Grown from individual donors\u2019 induced pluripotent stem cells, these models\u2014dubbed Multicellular Integrated Brains (miBrains)\u2014replicate key features and functions of human brain tissue, are readily customizable through gene editing, and can be produced in quantities that support large-scale research.<\/p>\n<p>Although each unit is smaller than a dime, miBrains may be worth a great deal to researchers and drug developers who need more complex living lab models to better understand brain biology and treat diseases.<\/p>\n<p>\u201cThe miBrain is the only in vitro system that contains all six major cell types that are present in the human brain,\u201d said Li-Huei Tsai, Picower Professor, director of The Picower Professor of Learning and Memory, and senior author of the study describing miBrains, published in the <i>Proceedings of the National Academy of Sciences.<\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new 3D human brain tissue platform developed by MIT researchers is the first to integrate all major brain cell types, including neurons, glial cells and the vasculature into a single culture. Grown from individual donors\u2019 induced pluripotent stem cells, these models\u2014dubbed Multicellular Integrated Brains (miBrains)\u2014replicate key features and functions of human brain tissue, are [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1902,11,47],"tags":[],"class_list":["post-223626","post","type-post","status-publish","format-standard","hentry","category-bioengineering","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223626","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=223626"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223626\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=223626"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=223626"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=223626"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}