{"id":223624,"date":"2025-10-18T04:16:56","date_gmt":"2025-10-18T09:16:56","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/new-antivirals-could-help-prevent-cold-sores-by-changing-cell-structures"},"modified":"2025-10-18T04:16:56","modified_gmt":"2025-10-18T09:16:56","slug":"new-antivirals-could-help-prevent-cold-sores-by-changing-cell-structures","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/new-antivirals-could-help-prevent-cold-sores-by-changing-cell-structures","title":{"rendered":"New antivirals could help prevent cold sores by changing cell structures"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/new-antivirals-could-help-prevent-cold-sores-by-changing-cell-structures2.jpg\"><\/a><\/p>\n<p>A class of antivirals called Pin1 inhibitors could reduce or stop outbreaks of herpes simplex virus 1 (HSV-1), the common infection behind oral herpes, according to new research published in <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354225001706?via%3Dihub=\" target=\"_blank\"><i>Antiviral Research<\/i><\/a>.<\/p>\n<p>HSV-1 causes sores around the mouth, commonly called cold sores or fever blisters. Most people are infected with HSV-1 in childhood, and between 50% and 90% of people worldwide have HSV-1. After the <a href=\"https:\/\/medicalxpress.com\/tags\/initial+infection\/\" rel=\"tag\" class=\"\">initial infection<\/a>, HSV-1 remains in the body and can reactivate throughout a person\u2019s life. While HSV-1 infections are usually mild, they can be serious and even deadly for people with suppressed immune systems. Finding new, more effective antivirals for this common illness is essential.<\/p>\n<p>Researchers focused on an enzyme called peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, or Pin1, that regulates protein stability, function, and cellular structure. When this <a href=\"https:\/\/medicalxpress.com\/tags\/enzyme\/\" rel=\"tag\" class=\"\">enzyme<\/a> is dysregulated, it can play a role in a variety of conditions, including obesity, cancer, <a href=\"https:\/\/medicalxpress.com\/tags\/heart+failure\/\" rel=\"tag\" class=\"\">heart failure<\/a>, and more. Viruses, such as cytomegalovirus (CMV) and SARS-CoV-2, are known to affect Pin1, and Pin1 <a href=\"https:\/\/medicalxpress.com\/tags\/inhibitors\/\" rel=\"tag\" class=\"\">inhibitors<\/a> have been developed to reduce the impact of these viruses.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A class of antivirals called Pin1 inhibitors could reduce or stop outbreaks of herpes simplex virus 1 (HSV-1), the common infection behind oral herpes, according to new research published in Antiviral Research. HSV-1 causes sores around the mouth, commonly called cold sores or fever blisters. Most people are infected with HSV-1 in childhood, and between [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-223624","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223624","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=223624"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223624\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=223624"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=223624"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=223624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}