{"id":223504,"date":"2025-10-16T03:37:11","date_gmt":"2025-10-16T08:37:11","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/bioelectronic-integrated-artificial-colon-eliminates-need-for-animal-testing"},"modified":"2025-10-16T03:37:11","modified_gmt":"2025-10-16T08:37:11","slug":"bioelectronic-integrated-artificial-colon-eliminates-need-for-animal-testing","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/bioelectronic-integrated-artificial-colon-eliminates-need-for-animal-testing","title":{"rendered":"Bioelectronic-integrated artificial colon eliminates need for animal testing"},"content":{"rendered":"<p><\/p>\n<p><iframe style=\"display: block; margin: 0 auto; width: 100%; aspect-ratio: 4\/3; object-fit: contain;\" src=\"https:\/\/www.youtube.com\/embed\/9j25I_Js6dc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope;\n   picture-in-picture\" allowfullscreen><\/iframe><\/p>\n<p>Researchers at the University of California, Irvine have developed a 3D human colon model integrated with bioelectronics to aid in colorectal cancer research and drug discovery. The \u201c3D in vivo mimicking human colon\u201d enables precision, personalized medicine and offers a more ethical, accurate and cost-effective alternative to traditional animal testing.<\/p>\n<p>In a paper <a href=\"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202506377\" target=\"_blank\">published<\/a> recently in the journal <i>Advanced Science<\/i>, researchers in UC Irvine\u2019s Samueli School of Engineering outline their creation of an approximately 5-by-10-millimeter replica that incorporates essential structural features of a colon, including liminal curvature, multilayered cellular organization and the spontaneous formation of cryptlike indentations.<\/p>\n<p>\u201cThe three-dimensional shapes, curves and crypts in our 3D-IVM-HC model are central to maintaining more realistic cell behavior even at a scaled-down size,\u201d said senior author Rahim Esfandyar-pour, UC Irvine assistant professor of electrical engineering and computer science.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at the University of California, Irvine have developed a 3D human colon model integrated with bioelectronics to aid in colorectal cancer research and drug discovery. The \u201c3D in vivo mimicking human colon\u201d enables precision, personalized medicine and offers a more ethical, accurate and cost-effective alternative to traditional animal testing. In a paper published recently [\u2026]<\/p>\n","protected":false},"author":662,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-223504","post","type-post","status-publish","format-standard","hentry","category-biotech-medical"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/662"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=223504"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223504\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=223504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=223504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=223504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}