{"id":223461,"date":"2025-10-15T23:15:04","date_gmt":"2025-10-16T04:15:04","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/acoustically-activatable-liposomes-as-a-translational-nanotechnology-for-site-targeted-drug-delivery-and-noninvasive-neuromodulation"},"modified":"2025-10-15T23:15:04","modified_gmt":"2025-10-16T04:15:04","slug":"acoustically-activatable-liposomes-as-a-translational-nanotechnology-for-site-targeted-drug-delivery-and-noninvasive-neuromodulation","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/acoustically-activatable-liposomes-as-a-translational-nanotechnology-for-site-targeted-drug-delivery-and-noninvasive-neuromodulation","title":{"rendered":"Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation"},"content":{"rendered":"<p style=\"padding-right: 20px\"><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/acoustically-activatable-liposomes-as-a-translational-nanotechnology-for-site-targeted-drug-delivery-and-noninvasive-neuromodulation.jpg\"><\/a><\/p>\n<p>Purohit <i>et al.<\/i> incorporate sucrose into drug-loaded lipid nanoparticle (LNP) formulations, which shifts the acoustic impedance in a way that triggers drug release upon exposure to focused ultrasound (FUS). By using FUS to both transiently open the blood-brain-barrier and to release drugs from their LNPs, various drugs were delivered into the brains of mice.<\/p>\n<hr>\n<p>Acoustically activatable nanocarriers made by incorporating 5% sucrose into liposomes release drug with low-intensity ultrasound, providing a readily clinically translatable system for both central and peripheral noninvasive neuromodulation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Purohit et al. incorporate sucrose into drug-loaded lipid nanoparticle (LNP) formulations, which shifts the acoustic impedance in a way that triggers drug release upon exposure to focused ultrasound (FUS). By using FUS to both transiently open the blood-brain-barrier and to release drugs from their LNPs, various drugs were delivered into the brains of mice. Acoustically [\u2026]<\/p>\n","protected":false},"author":636,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,4,47],"tags":[],"class_list":["post-223461","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-nanotechnology","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/636"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=223461"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223461\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=223461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=223461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=223461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}