{"id":223140,"date":"2025-10-09T03:23:55","date_gmt":"2025-10-09T08:23:55","guid":{"rendered":"https:\/\/lifeboat.com\/blog\/2025\/10\/chinese-medicine-extract-tetrandrines-precise-mechanism-of-action-opens-new-avenues-for-drug-discovery"},"modified":"2025-10-09T03:23:55","modified_gmt":"2025-10-09T08:23:55","slug":"chinese-medicine-extract-tetrandrines-precise-mechanism-of-action-opens-new-avenues-for-drug-discovery","status":"publish","type":"post","link":"https:\/\/lifeboat.com\/blog\/2025\/10\/chinese-medicine-extract-tetrandrines-precise-mechanism-of-action-opens-new-avenues-for-drug-discovery","title":{"rendered":"Chinese medicine extract tetrandrine\u2019s precise mechanism of action opens new avenues for drug discovery"},"content":{"rendered":"<p><a class=\"aligncenter blog-photo\" href=\"https:\/\/lifeboat.com\/blog.images\/chinese-medicine-extract-tetrandrines-precise-mechanism-of-action-opens-new-avenues-for-drug-discovery.jpg\"><\/a><\/p>\n<p>With this discovery, the researchers propose that tetrandrine can be used to disrupt processes critical to the survival and replication of viruses, such as Ebola and COVID-19, by targeting LIMP-2 to alter lysosomal calcium release.<\/p>\n<p>Importantly, these findings highlight lysosome-related mechanisms as a new frontier for <a href=\"https:\/\/phys.org\/tags\/drug+discovery\/\" rel=\"tag\" class=\"\">drug discovery<\/a>, offering novel strategies for treating diseases caused by calcium imbalance, including neurodegenerative disorders like Alzheimer\u2019s and Parkinson\u2019s, as well as certain metastatic cancers.<\/p>\n<p>Prof. Ko said, \u201cThis is the first time a function of LIMP-2 in calcium signaling has been uncovered. From a cell biology perspective, our study has revealed a completely new pathway for NAADP-regulated calcium signaling, through LIMP-2 and sphingosine. From an anti-viral treatment perspective, the study has identified LIMP-2 as a key target of tetrandrine for the treatment of Ebola virus infection, with broader applications in other antiviral therapies.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>With this discovery, the researchers propose that tetrandrine can be used to disrupt processes critical to the survival and replication of viruses, such as Ebola and COVID-19, by targeting LIMP-2 to alter lysosomal calcium release. Importantly, these findings highlight lysosome-related mechanisms as a new frontier for drug discovery, offering novel strategies for treating diseases caused [\u2026]<\/p>\n","protected":false},"author":427,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,47],"tags":[],"class_list":["post-223140","post","type-post","status-publish","format-standard","hentry","category-biotech-medical","category-neuroscience"],"_links":{"self":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223140","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/users\/427"}],"replies":[{"embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/comments?post=223140"}],"version-history":[{"count":0,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/posts\/223140\/revisions"}],"wp:attachment":[{"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/media?parent=223140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/categories?post=223140"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lifeboat.com\/blog\/wp-json\/wp\/v2\/tags?post=223140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}